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    • TCWG Subgroup: Greener Trials
      • Enabling Lower Carbon Clinical Trials (CiCT) Project
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Enabling Lower Carbon Clinical Trials (CiCT) Project

 

Publications

Griffiths J, Fox L, Williamson PR on behalf of the Low Carbon Clinical Trials Group. Quantifying the carbon footprint of clinical trials: guidance development and case studies. BMJ Open 2024;14:e075755. doi: 10.1136/bmjopen-2023-075755. https://bmjopen.bmj.com/content/14/1/e075755

Jessica Griffiths, Fiona Adshead, Rustam Al-Shahi Salman et al. Quantifying the carbon footprint of academic clinical trials: building the evidence base and hotspot identification, 09 May 2024, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-4363597/v1]

https://www.researchsquare.com/article/rs-4363597/v1

Carbon footprinting Guidance and data collection tools

• Latest version of guidance (with table of amendments and reason for updates at the end),
• data collection tool
• data collection questionnaire

Training

• Drop-in clinic

• Placeholder for: recorded footprinting training
• Placeholder for: worked example footprinting (The Footprint Trial protocol, with answers)

Funding awarded to the TMRP Greener Trials group

• MRC NIHR TMRP Funding award for patient animated video and drop in clinics
• UKRI Innovate UK Regulatory Science and Innovation Networks

Resources

Organisations/websites/training

• NIHR Carbon reduction guidelines NIHR Carbon Reduction Guidelines | NIHR
• Clinical Trials | Sustainable Healthcare Coalition (shcoalition.org)
• Academy of medical sciences report Enabling environmentally sustainable biomedical research | The Academy of Medical Sciences (acmedsci.ac.uk) 61695123 (acmedsci.ac.uk)
• Concordat for the Environmental Sustainability of Research and Innovation Practice Concordat for the Environmental Sustainability of Research and Innovation Practice (wellcome.org)
• SHADE Newsletter: Essential reading at the intersection of Sustainability, Health, AI, Digital technologies and the Environment SHADE Newsletter (beehiiv.com)
• Guide to Efficient Trial management Edition 7a, section 4.3 describes “sustainability in clinical trials
• Training - Centre for Sustainable Healthcare |
• Greener Monitoring UK CRC Guidance

Papers

• Clinical Research Risks, Climate Change, and Human Health | Research, Methods, Statistics | JAMA | JAMA Network
• Reducing the carbon footprint of research: experience from the NightLife study | BMJ Open
• Towards sustainable clinical trials | The BMJ
• Carbon cost of pragmatic randomised controlled trials: retrospective analysis of sample of trials | The BMJ
• Reducing the environmental impact of trials: a comparison of the carbon footprint of the CRASH-1 and CRASH-2 clinical trials | Trials | Full Text (biomedcentral.com)
• Carbon footprint of industry-sponsored late-stage clinical trials | BMJ Open
• The carbon footprint of clinical trials: a global survey on the status quo and current regulatory guidance - PubMed (nih.gov)
• An open-source tool to assess the carbon footprint of research - IOPscience
• Carbon-Footprint Analyses in RCTs — Toward Sustainable Clinical Practice | New England Journal of Medicine (nejm.org)
• Climate footpriGuidancent of industry-sponsored clinical research: an analysis of a phase-1 randomised clinical study and discussion of opportunities to reduce its impact | BMJ Open

Guidance

• The guide to efficient trial management
• Greener Monitoring UK CRC Guidance
• NIHR Carbon reduction guidelines NIHR Carbon Reduction Guidelines | NIHR