TMRP Doctoral Training Partnership

TMRP DTP Studentships

Are you interested in medical research that matters to patients and the NHS?

The MRC-NIHR Trials Methodology Research Partnership (TMRP) aims to Improve health by improving trials. Our MRC Doctoral Training Partnership presents an opportunity to undertake training for a PhD in trials methodology.

We have projects available for 2022 entry in various areas including statistics, data analytics and informatics, computer science, health economics, qualitative methods, mixed-methods, clinical medicine and psychology.

 

Professional development training and support

Students will become members of the TMRP, offering a broader spectrum of training activities and networking opportunities beyond their host Research Organisation. Students will be encouraged to join relevant TMRP working groups, where they will meet other PhD students, post-doctoral researchers and senior academic staff from relevant and complementary research themes. In addition to a structured ‘core’ training programme, we are able to provide a range of more specific training that students may choose to attend following consultation with their supervisors.

Our Associate Partner Research Organisations are able to offer opportunities for students that will include: research visits; internships with industry, regulatory bodies and clinical trials units; engagement with health professional and other research networks. We will encourage and support DTP students to apply for international internship schemes such as the UKRI UK-Canada Globalink Doctoral Exchange Scheme.

 

How to apply

You should apply for your first choice project, but can also tell us about up to two further projects you are interested in. Projects are only available at the universities listed and are non-transferable.

Before making an application, applicants should contact the project primary supervisor to find out more about the project and to discuss their interests in the research.

The deadline for completed application forms is 4pm (GMT) 18 February 2022. Click here for guidelines and the application form.

In addition to your application, we ask that you complete the equality, diversity and inclusion form and send a completed copy with your application form

Completed application forms must be returned to: enquiries@methodologyhubs.mrc.ac.uk.

Interviews of shortlisted candidates will take place online during the week of 21st March 2022. Please note our willingness to accept an application does not guarantee you will be invited for interview.

 

 

Projects

 

University of Liverpool

Embedding randomised trials within routine care - https://www.findaphd.com/phds/project/embedding-randomised-trials-within-routine-care/?p139109

Emulating biomarker-guided target trials using big data - https://www.findaphd.com/phds/project/emulating-biomarker-guided-target-trials-using-big-data/?p139108

Improving core outcome set uptake in trials - https://www.findaphd.com/phds/project/improving-core-outcome-set-uptake-in-trials/?p139110

Using existing data to optimise adaptive interventions in epilepsy - https://www.findaphd.com/phds/project/using-existing-data-to-optimise-adaptive-interventions-in-epilepsy/?p139106

 

Institute of Cancer Research

Enhancing the design, conduct and analysis of randomised adaptive trials through consensus-driven Statistical Analysis Plan guidance – https://www.findaphd.com/phds/project/enhancing-the-design-conduct-and-analysis-of-randomised-adaptive-trials-through-consensus-driven-statistical-analysis-plan-guidance/?p139164

Increasing representation of under-served groups in randomised oncology trials - https://www.findaphd.com/phds/project/increasing-representation-of-under-served-groups-in-randomised-oncology-trials/?p139163

 

Queen Mary University of London

Designing stepped wedge trials with more than one active intervention - https://www.findaphd.com/phds/project/designing-stepped-wedge-trials-with-more-than-one-active-intervention/?p139030

Moving beyond frequency tables for the analysis and presentation of harm outcomes in randomised controlled trials - https://www.findaphd.com/phds/project/moving-beyond-frequency-tables-for-the-analysis-and-presentation-of-harm-outcomes-in-randomised-controlled-trials/?p139032

Recruitment rates in pilot studies: what do they mean? - https://www.findaphd.com/phds/project/recruitment-rates-in-pilot-studies-what-do-they-mean/?p139031

Statistical methods for economic evaluation alongside stepped wedge cluster randomised controlled trial - https://www.findaphd.com/phds/project/statistical-methods-for-economic-evaluation-alongside-stepped-wedge-cluster-randomised-controlled-trial/?p139029

 

University of Aberdeen

Eliciting and incorporating patient’s opinions about missing data in randomised controlled trials - https://www.findaphd.com/phds/project/eliciting-and-incorporating-patient-s-opinions-about-missing-data-in-randomised-controlled-trials/?p138980

Exploring the effectiveness of audit and feedback to target healthcare professionals recruitment and retention behaviour in RCTs - https://www.findaphd.com/phds/project/exploring-the-effectiveness-of-audit-and-feedback-to-target-healthcare-professionals-recruitment-and-retention-behaviour-in-rcts/?p138989

Making it easier for trial teams to design inclusive trials - https://www.findaphd.com/phds/project/making-it-easier-for-trial-teams-to-design-inclusive-trials/?p138983

Optimising the collection and use of health economic data within trials - https://www.findaphd.com/phds/project/optimising-the-collection-and-use-of-health-economic-data-within-trials/?p138985

 

Bangor University

Event-based economic analyses of trials: Assessing current state of play and producing recommendations for future good practise - https://www.findaphd.com/phds/project/event-based-economic-analyses-of-trials-assessing-current-state-of-play-and-producing-recommendations-for-future-good-practise/?p138994

Extrapolation of economic outcomes beyond trial follow-up, are there additional challenges in paediatric trials? - https://www.findaphd.com/phds/project/extrapolation-of-economic-outcomes-beyond-trial-follow-up-are-there-additional-challenges-in-paediatric-trials/?p138995

Informing trial design through the application of linked pharmacometric-pharmacoeconomic analyses - https://www.findaphd.com/phds/project/informing-trial-design-through-the-application-of-linked-pharmacometric-pharmacoeconomic-analyses/?p138992

 

University of Birmingham

A methodological framework for incorporating multiple outcomes into hybrid implementation and effectiveness trials - https://www.findaphd.com/phds/project/a-methodological-framework-for-incorporating-multiple-outcomes-into-hybrid-implementation-and-effectiveness-trials/?p139002

A methodological framework for interpreting statistical results in randomised clinical trials - https://www.findaphd.com/phds/project/a-methodological-framework-for-interpreting-statistical-results-in-randomised-clinical-trials/?p138999

Design and analysis of randomised trials with imperfect dichotomous outcomes - https://www.findaphd.com/phds/project/design-and-analysis-of-randomised-trials-with-imperfect-dichotomous-outcomes/?p139018

OPTI-EX: Optimising exercise interventions for people at risk of dementia - https://www.findaphd.com/phds/project/opti-ex-optimising-exercise-interventions-for-people-at-risk-of-dementia/?p139003

 

University of Cambridge

Adaptive Designs for personalised treatment strategies in early phase clinical trials - https://www.findaphd.com/phds/project/adaptive-designs-for-personalised-treatment-strategies-in-early-phase-clinical-trials/?p139021

Trial within cohort adaptive enrichment designs - leveraging cohort longitudinal trajectories for shorter and efficient trials - https://www.findaphd.com/phds/project/trial-within-cohort-adaptive-enrichment-designs-leveraging-cohort-longitudinal-trajectories-for-shorter-and-efficient-trials/?p139027

 

University of Glasgow

Handling multiple outcomes in randomised trials of complex interventions - https://www.findaphd.com/phds/project/handling-multiple-outcomes-in-randomised-trials-of-complex-interventions/?p139089

Improving the Design of Vector Control Trials - https://www.findaphd.com/phds/project/improving-the-design-of-vector-control-trials/?p139034

Predictors of early trial termination using individual-level participant data and aggregate-level data from multiple trials - https://www.findaphd.com/phds/project/predictors-of-early-trial-termination-using-individual-level-participant-data-and-aggregate-level-data-from-multiple-trials/?p139039

The application of surrogate endpoints in clinical trials - https://www.findaphd.com/phds/project/the-application-of-surrogate-endpoints-in-clinical-trials/?p139090

 

University of Leeds

Assessing the feasibility of complex and innovative trial designs - https://www.findaphd.com/phds/project/assessing-the-feasibility-of-complex-and-innovative-trial-designs/?p139270 

Developing a toolkit to facilitate surgical trial implementation and delivery – applying knowledge from qualitative research in trials - https://www.findaphd.com/phds/project/developing-a-toolkit-to-facilitate-surgical-trial-implementation-and-delivery-applying-knowledge-from-qualitative-research-in-trials/?p139273

Outcomes for Pressure Ulcer Trials (OUTPUTs): development of outcome measurement instruments for core domain outcomes - https://www.findaphd.com/phds/project/outcomes-for-pressure-ulcer-trials-outputs-development-of-outcome-measurement-instruments-for-core-domain-outcomes/?p139278

 

University College London

Advancing the development of the DURATIONS design in practice - https://www.findaphd.com/phds/project/advancing-the-development-of-the-durations-design-in-practice/?p139028

Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial - https://www.findaphd.com/phds/project/exploring-methods-for-borrowing-evidence-across-baskets-or-subgroups-in-a-clinical-trial/?p139022

Uplifting the standard of monitoring in clinical trials – developing evidence and tools - https://www.findaphd.com/phds/project/uplifting-the-standard-of-monitoring-in-clinical-trials-developing-evidence-and-tools/?p139020

Using observational data and/or single arm studies to inform trial design: can we make our trials smaller and shorter? - https://www.findaphd.com/phds/project/using-observational-data-and-or-single-arm-studies-to-inform-trial-design-can-we-make-our-trials-smaller-and-shorter/?p139025

 

Newcastle University

Embedding trials in routine practice: identifying and overcoming barriers to using routinely collected data in studies with families affected by multiple long-term conditions or disadvantage - https://www.findaphd.com/phds/project/embedding-trials-in-routine-practice-identifying-and-overcoming-barriers-to-using-routinely-collected-data-in-studies-with-families-affected-by-multiple-long-term-conditions-or-disadvantage/?p139115 

Improving methods for analysing complex responder and relapse endpoints in Lupus and other chronic complex conditions - https://www.findaphd.com/phds/project/improving-methods-for-analysing-complex-responder-and-relapse-endpoints-in-lupus-and-other-chronic-complex-conditions/?p139111

Innovative designs for diagnostic test evaluation trials - https://www.findaphd.com/phds/project/innovative-designs-for-diagnostic-test-evaluation-trials/?p139117

Random allocation methods and implications for statistical analysis - https://www.findaphd.com/phds/project/random-allocation-methods-and-implications-for-statistical-analysis/?p139114

Trial-based cost-effectiveness analysis with missing values using multiple imputation and controlled multiple imputation: a mixed-methods practical framework - https://www.findaphd.com/phds/project/trial-based-cost-effectiveness-analysis-with-missing-values-using-multiple-imputation-and-controlled-multiple-imputation-a-mixed-methods-practical-framework/?p139112

 

University of Plymouth

Modelling multiple ordinal outcomes in clinical trials - https://www.findaphd.com/phds/project/modelling-multiple-ordinal-outcomes-in-clinical-trials/?p139036

Promoting trial participation in rural and coastal communities - https://www.findaphd.com/phds/project/promoting-trial-participation-in-rural-and-coastal-communities/?p139037