TMRP Doctoral Training Partnership

TMRP DTP Studentships

Are you interested in medical research that matters to patients and the NHS?

The MRC-NIHR Trials Methodology Research Partnership (TMRP) aims to Improve health by improving trials. Our MRC Doctoral Training Partnership presents an opportunity to undertake training for a PhD in trials methodology.

We have projects available for 2022 entry in various areas including statistics, data analytics and informatics, computer science, health economics, qualitative methods, mixed-methods, clinical medicine and psychology.


Professional development training and support

Students will become members of the TMRP, offering a broader spectrum of training activities and networking opportunities beyond their host Research Organisation. Students will be encouraged to join relevant TMRP working groups, where they will meet other PhD students, post-doctoral researchers and senior academic staff from relevant and complementary research themes. In addition to a structured ‘core’ training programme, we are able to provide a range of more specific training that students may choose to attend following consultation with their supervisors.

Our Associate Partner Research Organisations are able to offer opportunities for students that will include: research visits; internships with industry, regulatory bodies and clinical trials units; engagement with health professional and other research networks. We will encourage and support DTP students to apply for international internship schemes such as the UKRI UK-Canada Globalink Doctoral Exchange Scheme.


How to apply

You should apply for your first choice project, but can also tell us about up to two further projects you are interested in. Projects are only available at the universities listed and are non-transferable.

Before making an application, applicants should contact the project primary supervisor to find out more about the project and to discuss their interests in the research.

The deadline for completed application forms is 4pm (GMT) 18 February 2022. Click here for guidelines and the application form.

In addition to your application, we ask that you complete the equality, diversity and inclusion form and send a completed copy with your application form

Completed application forms must be returned to:

Interviews of shortlisted candidates will take place online during the week of 21st March 2022. Please note our willingness to accept an application does not guarantee you will be invited for interview.





University of Liverpool

Embedding randomised trials within routine care -

Emulating biomarker-guided target trials using big data -

Improving core outcome set uptake in trials -

Using existing data to optimise adaptive interventions in epilepsy -


Institute of Cancer Research

Enhancing the design, conduct and analysis of randomised adaptive trials through consensus-driven Statistical Analysis Plan guidance –

Increasing representation of under-served groups in randomised oncology trials -


Queen Mary University of London

Designing stepped wedge trials with more than one active intervention -

Moving beyond frequency tables for the analysis and presentation of harm outcomes in randomised controlled trials -

Recruitment rates in pilot studies: what do they mean? -

Statistical methods for economic evaluation alongside stepped wedge cluster randomised controlled trial -


University of Aberdeen

Eliciting and incorporating patient’s opinions about missing data in randomised controlled trials -

Exploring the effectiveness of audit and feedback to target healthcare professionals recruitment and retention behaviour in RCTs -

Making it easier for trial teams to design inclusive trials -

Optimising the collection and use of health economic data within trials -


Bangor University

Event-based economic analyses of trials: Assessing current state of play and producing recommendations for future good practise -

Extrapolation of economic outcomes beyond trial follow-up, are there additional challenges in paediatric trials? -

Informing trial design through the application of linked pharmacometric-pharmacoeconomic analyses -


University of Birmingham

A methodological framework for incorporating multiple outcomes into hybrid implementation and effectiveness trials -

A methodological framework for interpreting statistical results in randomised clinical trials -

Design and analysis of randomised trials with imperfect dichotomous outcomes -

OPTI-EX: Optimising exercise interventions for people at risk of dementia -


University of Cambridge

Adaptive Designs for personalised treatment strategies in early phase clinical trials -

Trial within cohort adaptive enrichment designs - leveraging cohort longitudinal trajectories for shorter and efficient trials -


University of Glasgow

Handling multiple outcomes in randomised trials of complex interventions -

Improving the Design of Vector Control Trials -

Predictors of early trial termination using individual-level participant data and aggregate-level data from multiple trials -

The application of surrogate endpoints in clinical trials -


University of Leeds

Assessing the feasibility of complex and innovative trial designs - 

Developing a toolkit to facilitate surgical trial implementation and delivery – applying knowledge from qualitative research in trials -

Outcomes for Pressure Ulcer Trials (OUTPUTs): development of outcome measurement instruments for core domain outcomes -


University College London

Advancing the development of the DURATIONS design in practice -

Exploring methods for borrowing evidence across baskets or subgroups in a clinical trial -

Uplifting the standard of monitoring in clinical trials – developing evidence and tools -

Using observational data and/or single arm studies to inform trial design: can we make our trials smaller and shorter? -


Newcastle University

Embedding trials in routine practice: identifying and overcoming barriers to using routinely collected data in studies with families affected by multiple long-term conditions or disadvantage - 

Improving methods for analysing complex responder and relapse endpoints in Lupus and other chronic complex conditions -

Innovative designs for diagnostic test evaluation trials -

Random allocation methods and implications for statistical analysis -

Trial-based cost-effectiveness analysis with missing values using multiple imputation and controlled multiple imputation: a mixed-methods practical framework -


University of Plymouth

Modelling multiple ordinal outcomes in clinical trials -

Promoting trial participation in rural and coastal communities -