CTMC2011 »  Pragmatic Trials

Session: Pragmatic Trials

Pragmatic trials estimate the effectiveness of a treatment, device or therapy in everyday healthcare practice. The characteristics of a pragmatic trial are that the variability in the sample is reflective of the entire patient population in which the treatment is indicated; comparison is usually best current practice; placebos are not usually used and hence patient and healthcare practitioners are not always blinded; the outcomes are of health policy and practice relevance and may include an economic appraisal. The trials are usually large, and run over many centres to maximise the generalisability of the findings.


- provide an overview of the differences between exploratory and pragmatic trials

- provide an update of new designs and methods being used in pragmatic trials

- encourage a discussion of the methodological and practical challenges in running pragmatic trials

Oral Presentations

Click on the links below to view the presentations.

 Pragmatic trials – how pragmatic can we be?

Treatment success in pragmatic RCTs: a review of trials funded by the UK HTA programme

Alternative approaches to tuberculosis treatment evaluation: the role of pragmatic trials

Pragmatic trials of non-NHS interventions: experiences from a randomised controlled trial of the strengthening families 10-14 UK programme (SFP10-14 UK)

Statistical issues in the design of randomised surgical trials: a practical example of the possible solutions

Holding on to power: why confidence intervals are not (usually) the best basis for sample size calculations