Home Page »  Methodology Conference 2015 »  CTMC2011 »  Retention and Adherence

Session: Retention and Adherence

Difficulties with retaining participants in a trial and in dealing with lack of adherence to the trial intervention are common problems in trials. These issues are relevant for trials of long-term treatments (eg in TB and HIV) and of complex interventions.  It may be an issue for the conduct and analysis of trials rather than design.  

Aims

- review and discuss trials of methods to improve retention and adherence

- discuss the strengths and weaknesses of cluster and other designs to reduce contamination

- discuss the design of feasibility studies to examine and improve adherence to trial interventions (rather than concentrating on recruitment)

- discuss the implications of poor adherence – Is it a problem or is it a useful indicator of poor effectiveness of an intervention?

- examine the interpretation of ITT analyses with contamination between arms

Oral Presentations

Click on the links below to view the presentations.

Retention in clinical trials

Departure from treatment protocol in published RCTs: a review

Use of the medication event monitoring system for assessing medication adherence for chronic conditions: Results from a 12 month trial of patients in remission with ulcerative colitis

Adherence in a randomised controlled trial comparing liberal and restrictive red blood cell transfusion thresholds after cardiac surgery