Session: Retention and Adherence
Difficulties with retaining participants in a
trial and in dealing with lack of adherence to the trial
intervention are common problems in trials. These issues are
relevant for trials of long-term treatments (eg in TB and HIV) and
of complex interventions. It may be an issue for the conduct
and analysis of trials rather than design.
Aims
- review and discuss trials of methods to
improve retention and adherence
- discuss the strengths and weaknesses of cluster and other
designs to reduce contamination
- discuss the design of feasibility studies to examine and
improve adherence to trial interventions (rather than concentrating
on recruitment)
- discuss the implications of poor adherence – Is it a problem
or is it a useful indicator of poor effectiveness of an
intervention?
- examine the interpretation of ITT analyses with contamination
between arms
Oral Presentations
Click on the links below to view the presentations.
Retention
in clinical trials
Departure
from treatment protocol in published RCTs: a review
Use of
the medication event monitoring system for assessing medication
adherence for chronic conditions: Results from a 12 month trial of
patients in remission with ulcerative colitis
Adherence in a
randomised controlled trial comparing liberal and restrictive red
blood cell transfusion thresholds after cardiac surgery