Session: Pragmatic Trials
Pragmatic trials estimate the effectiveness of
a treatment, device or therapy in everyday healthcare practice. The
characteristics of a pragmatic trial are that the variability in
the sample is reflective of the entire patient population in which
the treatment is indicated; comparison is usually best current
practice; placebos are not usually used and hence patient and
healthcare practitioners are not always blinded; the outcomes are
of health policy and practice relevance and may include an economic
appraisal. The trials are usually large, and run over many centres
to maximise the generalisability of the findings.
Aims
- provide an overview of the differences
between exploratory and pragmatic trials
- provide an update of new designs and methods
being used in pragmatic trials
- encourage a discussion of the methodological
and practical challenges in running pragmatic trials
Oral Presentations
Click on the links below to view the presentations.
Pragmatic
trials – how pragmatic can we be?
Treatment success in
pragmatic RCTs: a review of trials funded by the UK HTA
programme
Alternative
approaches to tuberculosis treatment evaluation: the role of
pragmatic trials
Pragmatic trials of
non-NHS interventions: experiences from a randomised controlled
trial of the strengthening families 10-14 UK programme (SFP10-14
UK)
Statistical issues
in the design of randomised surgical trials: a practical example of
the possible solutions
Holding on
to power: why confidence intervals are not (usually) the best basis
for sample size calculations