Accurate and consistent selection and
reporting of clinical and patient reported outcomes in trials is
critical to inform systematic reviews and meta-analyses, to allow
cross study comparisons and to reduce reporting bias. Inclusion of
patient reported outcomes (PROs) alongside clinical outcomes in
trials has greatly increased, but PROs still seem to be under used
once their relevance to clinical decision-making has been taken
into account. Selection and reporting of valid and reliable
clinical and patient reported outcomes in trials is needed. There
is also a need to improve methods for reporting patient reported
outcomes from trials to ensure that they are clinically meaningful,
understood by clinicians, and used in clinical practice.
- review strategies for the process of
designing trials with PRO endpoints
- address the challenges of PRO and clinical
data analyses and presentation with examples of successes and
- consider future research on strategies to
optimize the use of PROs in trials
- highlight methods for developing core
outcomes sets to be reported as a minimum in trials
- review methods for incorporating patient
reported outcomes into core outcomes sets
Click on the links below to view the presentations.
outcomes: Where are we and where are we heading?
Use of an objective
measure of time to recovery after cardiac surgery: the STET
randomised controlled trial
outcomes: misinference from ordinal scales?
Win Ratio: a new
approach to the analysis of composite endpoints in clinical trials
based on clinical priorities